No, wine is not low histamine. In fact, wine is one of the worst things you can consume if you have histamine intolerance, because wine contains both ethanol (alcohol) and high levels of histamine. Both histamine and ethanol are cleared from your system using the same enzyme, so if your histamine levels are already high, drinking wine would both increase your histamine levels and keep them high. In addition, most wines have added sulfates, to which a small percentage of the population is sensitive. Some people can tolerate very small amounts of natural white wines, but there is no true low histamine wine.