No, walnuts are not low histamine. They’re also not technically high in histamine, but they are high in other biogenic amines, which often compete with histamine to be cleared from the body. Therefore, many people experiencing histamine intolerance cannot handle walnuts in the first few months of the diet and are advised to stay away. If you’ve ever had a reaction to a tree nut, or any other nut or seed, take caution when reintroducing walnuts. However, once you do reintroduce them, they’re a great source of inflammation-fighting omega 3 fatty acids.