No, gin is not low histamine. But if you do want to drink alcohol with histamine intolerance or MCAD, unaged gin is one of the least harmful choices out there. While it still contains alcohol and some histamine, if your bucket is low, you should be able to tolerate a small amount every once in awhile. With the help of some diamine oxidase (DAO), the enzyme which clears both histamine and alcohol from your system, many people with histamine issues can tolerate up to one ounce of gin per hour. This is enough to make one or two small cocktails by mixing gin with seltzer water or a low histamine juice, though adding any sweeteners will increase the inflammation load. You can muddle some fresh herbs and berries to mix up something fancy, but just avoid the tonic water (high histamine).