Yes, agave syrup is low histamine in small amounts. However in large amounts, agave syrup is just as inflammatory as any other sugar, even though it has a relatively low glycemic index score of roughly 15. This is even lower than that of honey, another popular sweetener for histamine intolerance, yet the root reason to limit consumption is the same for both: gut inflammation. After you consume them, the sugars in agave syrup go directly to the gut where they feed bad bacteria, some of which create histamine as a by-product. Therefore even though agave syrup is low histamine, it can still contribute to increased histamine levels, so consume in moderation.